Protein Alignment Tool

Protein sequences stored in UniProt have a CRC64 checksum.  This means that it is possible to take an arbitrary sequence (with or without a known identifier), calculate the CRC64 checksum for it, and then search UniProt for that specific sequence.  There are two problems with this:

1. UniProt does not provide any web services for querying their database.  I’ll check again, but, I don’t see it
2. There is a low possibility of collision; that is, two sequences may produce the same CRC64 checksum.

On Nature Precedings I came across A SEquence Globally Unique IDentifier (SEGUID) Proteome Database that solves the two problems above.

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